Milk Fermented by Lactobacillus paracasei NCC 2461 (ST11) Modulates the Immune Response and Microbiota to Exert its Protective Effects Against Salmonella typhimurium Infection in Mice.
Probiotics Antimicrob Proteins
; 12(4): 1398-1408, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-31970649
ABSTRACT
Probiotics form a promising strategy to maintain intestinal health. Milks fermented with probiotic strains, such as the Lactobacillus paracasei ST11, are largely commercialized in Brazil and form a low-cost alternative to probiotic pharmaceutical formulations. In this study, we assessed the probiotic effects of milk fermented by L. paracasei ST11 (administered through fermented milk) in a Salmonella typhimurium infection model in BALB/c mice. We observed in this murine model that the applied probiotic conferred protective effects against S. typhimurium infection, since its administration reduced mortality, weight loss, translocation to target organs (liver and spleen) and ileum injury. Moreover, a reduction in the mRNA expression of pro-inflammatory cytokines such as IFN-γ, IL-6, TNF-α and IL-17 in animals that received the probiotic before challenge was observed. Additionally, the ileum microbiota was better preserved in these animals. The present study highlights a multifactorial protective aspect of this commercial probiotic strain against a common gastrointestinal pathogen.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
/
3_ND
/
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
2_enfermedades_transmissibles
/
3_neglected_diseases
/
3_zoonosis
/
6_obesity
Asunto principal:
Infecciones por Salmonella
/
Regulación de la Expresión Génica
/
Probióticos
/
Productos Lácteos Cultivados
/
Resistencia a la Enfermedad
/
Lacticaseibacillus paracasei
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Probiotics Antimicrob Proteins
Año:
2020
Tipo del documento:
Article
País de afiliación:
Brasil