Single nucleotide polymorphisms in the dual specificity phosphatase genes and risk of necrotizing enterocolitis in premature infant.
J Neonatal Perinatal Med
; 13(3): 373-380, 2020.
Article
en En
| MEDLINE
| ID: mdl-31985475
ABSTRACT
BACKGROUND:
Differences in the susceptibility of preterm infants to develop necrotizing enterocolitis (NEC) implicate potential genetic differences in response to the inflammatory stimuli leading to NEC. Dual specificity phosphatases (DUSPs) are a key suppressor pathway of the mitogen-activated protein kinase (MAPK) pro-inflammatory signaling pathway. We hypothesized that inherited single nucleotide polymorphisms (SNPs) in DUSP genes contribute to NEC susceptibility in premature infants.METHODS:
Patients admitted between 2010 and 2015 born atâ< â32 weeks GA and≤1,500âg BW with stage II+NEC (cases; nâ=â50) and age, weight-matched controls (nâ=â38) were included. Blood samples were collected for DNA isolation. Agena Mass Array assay was used to examine 31 SNPs in 9 different DUSP genes. Calculated minor allele frequencies (MAF) for cases and controls were compared using χ2 and logistic regression.RESULTS:
The presence of the rs704074 SNP was associated with a 48% decreased risk of developing NEC (OR 0.52; 95% CI 0.27- 1.01, pâ=â0.04). The odds of surgical NEC decreased by 78% (OR 0.22; 95% CI 0.06- 0.84, pâ=â0.027) for each copy of rs704074/G allele in patients with NEC.CONCLUSION:
In this small single-center pilot study, DUSP-6 SNP (rs704074) was associated with a lower risk of developing NEC and surgical NEC, the most severe form of NEC, in preterm infants.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_zoonosis
Asunto principal:
Recien Nacido Prematuro
/
Enterocolitis Necrotizante
/
Fosfatasa 6 de Especificidad Dual
/
Enfermedades del Prematuro
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Newborn
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Neonatal Perinatal Med
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos