Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues.
Mol Cell Oncol
; 7(1): 1692643, 2020.
Article
en En
| MEDLINE
| ID: mdl-31993501
ABSTRACT
We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Mol Cell Oncol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Dinamarca