Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway.

Yang, Shu; Ma, Chuanrui; Wu, Han; Zhang, Hao; Yuan, Fengyi; Yang, Guangyan; Yang, Qi; Jia, Lijing; Liang, Zhen; Kang, Lin

Yang, Shu; Ma, Chuanrui; Wu, Han; Zhang, Hao; Yuan, Fengyi; Yang, Guangyan; Yang, Qi; Jia, Lijing; Liang, Zhen; Kang, Lin.

Afiliación

Yang S; Department of Endocrinology, The 2nd Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.
Ma C; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China; Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin, China.
Wu H; Department of Endocrinology, The 2nd Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China; Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Ac
Zhang H; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China; Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin, China.
Yuan F; Department of Endocrinology, The 2nd Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.
Yang G; Department of Endocrinology, The 2nd Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.
Yang Q; Department of Endocrinology, The 2nd Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.
Jia L; Department of Endocrinology, The 2nd Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China. Electronic address: jialijing2012@126.com.
Liang Z; Department of Endocrinology, The 2nd Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China. Electronic address: liang.zhen@szhospital.com.
Kang L; Department of Endocrinology, The 2nd Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China. Electronic address: Kang.lin@szhospital.com.

Pharmacol Res ; 153: 104678, 2020 03.

Article en En | MEDLINE | ID: mdl-32014572

Asunto(s)

Diabetes Mellitus Experimental/tratamiento farmacológico; Diabetes Mellitus Tipo 2/tratamiento farmacológico; Nefropatías Diabéticas/tratamiento farmacológico; Isoflavonas/uso terapéutico; Receptores de Adiponectina/metabolismo; Animales; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Tipo 2/metabolismo; Nefropatías Diabéticas/metabolismo; Células Endoteliales/efectos de los fármacos; Células Endoteliales/metabolismo; Endotelio Vascular/efectos de los fármacos; Endotelio Vascular/metabolismo; Técnicas de Silenciamiento del Gen; Humanos; Glomérulos Renales/efectos de los fármacos; Glomérulos Renales/metabolismo; Lipopolisacáridos/farmacología; Ratones Endogámicos; Receptores de Adiponectina/genética; Transducción de Señal; Células THP-1

Palabras clave

Adiponectin receptor1/2; Diabetic nephropathy; Endothelium function; Eosin (PubChem CID: 11048); Hematoxylin (PubChem CID: 442514); Macrophage polarization; Oil red O (PubChem CID: 62330); Tectorigenin; Tectorigenin (PubChem CID: 5281811)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Nefropatías Diabéticas / Receptores de Adiponectina / Isoflavonas Límite: Animals / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China

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