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Adverse Drug Reactions in Selected Wards of the Yangon General Hospital and Yangon Specialty Hospital During the First Quarter of 2019: An Active Pharmacovigilance Study in Myanmar.
May, Lwin Moe; Figueras, Albert; Linn, Ye Htut; Htike, Maw Than; San, Mi Kun Kaw; Pyae, Nyein Chan; Aye, Khin Hnin; Aung, Ei Ei; Win, Nilar; Thawda, Wine; Linn, Zin Wah; Kyaw, Yin Min; Min, Ya; Than, Zaw Win; Khaing, Moe Pan; Win, Thurein; Htet, Pyi Phyo; Aye, Nu Nu.
Afiliación
  • May LM; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar. lwinmoemay@gmail.com.
  • Figueras A; Fundació Institut Català de Farmacologia, Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Linn YH; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Htike MT; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • San MKK; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Pyae NC; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Aye KH; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Aung EE; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Win N; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Thawda W; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Linn ZW; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Kyaw YM; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Min Y; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Than ZW; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Khaing MP; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Win T; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Htet PP; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
  • Aye NN; Department of Pharmacology, University of Medicine 1, Yangon, No. 245, Myoma-Kyaung Street, Lanmadaw Township, Yangon, 11131, Myanmar.
Drugs Real World Outcomes ; 7(2): 109-117, 2020 Jun.
Article en En | MEDLINE | ID: mdl-32040848
ABSTRACT

BACKGROUND:

Previous studies in Europe and the USA have reported a high prevalence of adverse drug reactions (ADRs), but data on local ADRs in Myanmar are sparse.

OBJECTIVE:

Our objective was to study ADRs in patients admitted to selected wards of Yangon General Hospital (YGH) and Yangon Specialty Hospital (YSH), Myanmar.

METHODS:

This was a prospective observational study in three hospital wards during the first quarter of 2019. Suspected ADRs were carefully investigated in a face-to-face interview with each patient and via review of clinical records. Patients transferred to other wards or discharged were followed-up by the researchers until day 28 after admission. ADRs were divided into those that (1) led to the admission and (2) occurred during the hospital stay or after discharge (up to day 28 after admission).

RESULTS:

A total of 65 ADRs were identified, with 47 (29.4%) of 160 patients experiencing at least one ADR. Among these, 16 (24.6%) had led to hospital admission and 49 (75.4%) occurred in 31 patients during their hospital stay. Of 160 patients, 21 had taken at least one herbal remedy and six of these developed an ADR. Five ADR-drug associations (hypokalaemia with methylprednisolone, increased transaminase levels with standard antituberculosis drugs, upper gastrointestinal bleeding with nonsteroidal anti-inflammatory drugs, constipation with tramadol, and increased transaminase levels with herbal remedies) represented 18 (27.7%) of the 65 ADRs in this study. According to the Schumock and Thornton preventability scale, more than half of these ADRs (35 [53.9%]) were preventable.

CONCLUSION:

The present study highlights the existence of ADRs among patients attending these hospitals. The implementation of active pharmacovigilance in hospitals could be a helpful first step to improving the awareness of unwanted effects of medicines and patient safety, as well as a way to strengthen the national pharmacovigilance system in countries such as Myanmar.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_tuberculosis Tipo de estudio: Observational_studies / Qualitative_research / Risk_factors_studies Idioma: En Revista: Drugs Real World Outcomes Año: 2020 Tipo del documento: Article País de afiliación: Myanmar
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_tuberculosis Tipo de estudio: Observational_studies / Qualitative_research / Risk_factors_studies Idioma: En Revista: Drugs Real World Outcomes Año: 2020 Tipo del documento: Article País de afiliación: Myanmar