Prevention and treatment of temporal lobe epilepsy: lessons from hepatitis B story!
Int J Neurosci
; 130(11): 1151-1155, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-32053411
ABSTRACT
Temporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy and hippocampal sclerosis (HS) is the most common pathological substrate of TLE. Considering the significant consequences of uncontrolled seizures (e.g. increased morbidity and mortality), epilepsy prevention remains a necessity that potentially could save many lives. Human herpes virus-6 (HHV-6) has been linked to TLE in humans. The relationship between HHV-6 and HS-TLE could be attributed to a neuro-inflammatory cascade triggered by the infection, involving direct neuronal damage and production of several pro-inflammatory cytokines under certain conditions that are still incompletely understood. Hepatitis B virus (HBV) infection is another chronic viral infection with a life-long latency. HBV infection is linked to various clinical conditions, including liver cirrhosis. There are currently three ways to fight HBV infection and its consequences; primary prevention (by vaccination), secondary prevention (by drug therapy), and tertiary prevention (by liver transplantation). Considering the similarities between the natural histories of HHV-6 and HBV infections, and also the successful strategies which are currently available to fight HBV infection and its long-term consequences, here, we propose three strategies to fight HHV-6 and its possible long-term consequence (i.e. HS-TLE) Primary prevention by developing vaccines to prevent HHV-6 infection; Secondary prevention by considering trials of antiviral drugs to treat HHV-6 infection, when it happens in the childhood to hopefully prevent its long-term consequences; and, Tertiary prevention by stem cell therapy for drug-resistant epilepsy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
/
4_TD
/
6_ODS3_enfermedades_notrasmisibles
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Problema de salud:
1_doencas_nao_transmissiveis
/
2_enfermedades_transmissibles
/
2_muertes_prevenibles
/
4_hepatitis
/
6_digestive_diseases
/
6_epilepsy
/
7_infections
/
7_neonatal_care_health
Asunto principal:
Antivirales
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Vacunas Virales
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Herpesvirus Humano 6
/
Infecciones por Roseolovirus
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Trasplante de Células Madre
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Epilepsia del Lóbulo Temporal
/
Hepatitis B
Límite:
Humans
Idioma:
En
Revista:
Int J Neurosci
Año:
2020
Tipo del documento:
Article
País de afiliación:
Irán