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Activity of Cefiderocol and Comparators against Isolates from Cancer Patients.
Rolston, Kenneth V I; Gerges, Baghat; Shelburne, Samuel; Aitken, Samuel L; Raad, Issam; Prince, Randall A.
Afiliación
  • Rolston KVI; Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA krolston@mdanderson.org.
  • Gerges B; Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Shelburne S; Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Aitken SL; Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Raad I; Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Prince RA; Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Antimicrob Agents Chemother ; 64(5)2020 04 21.
Article en En | MEDLINE | ID: mdl-32071053
ABSTRACT
Cefiderocol inhibited 97.5% of 478 Gram-negative isolates from cancer patients at ≤4 mg/liter. It had potent activity against extended-spectrum ß-lactamase-positive Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae (CRE), and nonfermenting Gram-negative bacilli, including Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter species isolates. Amikacin, ceftazidime-avibactam, and meropenem had appreciable activity against non-CRE Enterobacteriaceae No comparators were active against multidrug-resistant P. aeruginosa isolates. Only trimethoprim-sulfamethoxazole had appreciable activity against S. maltophilia isolates. Overall, cefiderocol was associated with the lowest level of resistance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_neglected_diseases / 3_zoonosis Asunto principal: Amicacina / Ceftazidima / Cefalosporinas / Compuestos de Azabiciclo / Meropenem / Bacterias Gramnegativas / Antibacterianos Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_neglected_diseases / 3_zoonosis Asunto principal: Amicacina / Ceftazidima / Cefalosporinas / Compuestos de Azabiciclo / Meropenem / Bacterias Gramnegativas / Antibacterianos Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos