Materials Characterization of Cranial Simulants for Blast-Induced Traumatic Brain Injury.
Mil Med
; 185(Suppl 1): 205-213, 2020 01 07.
Article
en En
| MEDLINE
| ID: mdl-32074306
ABSTRACT
INTRODUCTION:
The mechanical response of brain tissue to high-speed forces in the blast and blunt traumatic brain injury is poorly understood. Object-to-object variation and interspecies differences are current limitations in animal and cadaver studies conducted to study damage mechanisms. Biofidelic and transparent tissue simulants allow the use of high-speed optical diagnostics during a blast event, making it possible to observe deformations and damage patterns for comparison to observed injuries seen post-mortem in traumatic brain injury victims.METHODS:
Material properties of several tissue simulants were quantified using standard mechanical characterization techniques, that is, shear rheometric, tensile, and compressive testing.RESULTS:
Polyacrylamide simulants exhibited the best optical and mechanical property matching with the fewest trade-offs in the design of a cranial test object. Polyacrylamide gels yielded densities of ~1.04 g/cc and shear moduli ranging 1.3-14.55 kPa, allowing gray and white matter simulant tuning to a 30-35% difference in shear for biofidelity.CONCLUSIONS:
These materials are intended for use as layered cranial phantoms in a shock tube and open field blasts, with focus on observing phenomena occurring at the interfaces of adjacent tissue simulant types or material-fluid boundaries. Mechanistic findings from these studies may be used to inform the design of protective gear to mitigate blast injuries.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Traumatismos por Explosión
/
Lesiones Traumáticas del Encéfalo
/
Ciencia de los Materiales
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mil Med
Año:
2020
Tipo del documento:
Article