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Materials Characterization of Cranial Simulants for Blast-Induced Traumatic Brain Injury.
Wermer, Anna; Kerwin, Joseph; Welsh, Kelsea; Mejia-Alvarez, Ricardo; Tartis, Michaelann; Willis, Adam.
Afiliación
  • Wermer A; Department of Chemical Engineering, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, NM 87801.
  • Kerwin J; Department of Mechanical Engineering, Michigan State University, 1449 Engineering Research Ct. A117, East Lansing, MI 48824.
  • Welsh K; Department of Chemical Engineering, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, NM 87801.
  • Mejia-Alvarez R; Department of Mechanical Engineering, Michigan State University, 1449 Engineering Research Ct. A117, East Lansing, MI 48824.
  • Tartis M; Department of Chemical Engineering, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, NM 87801.
  • Willis A; Department of Neurology, San Antonio Military Medical Center, 3551 Roger Brooke Dr, San Antonio, TX 78219.
Mil Med ; 185(Suppl 1): 205-213, 2020 01 07.
Article en En | MEDLINE | ID: mdl-32074306
ABSTRACT

INTRODUCTION:

The mechanical response of brain tissue to high-speed forces in the blast and blunt traumatic brain injury is poorly understood. Object-to-object variation and interspecies differences are current limitations in animal and cadaver studies conducted to study damage mechanisms. Biofidelic and transparent tissue simulants allow the use of high-speed optical diagnostics during a blast event, making it possible to observe deformations and damage patterns for comparison to observed injuries seen post-mortem in traumatic brain injury victims.

METHODS:

Material properties of several tissue simulants were quantified using standard mechanical characterization techniques, that is, shear rheometric, tensile, and compressive testing.

RESULTS:

Polyacrylamide simulants exhibited the best optical and mechanical property matching with the fewest trade-offs in the design of a cranial test object. Polyacrylamide gels yielded densities of ~1.04 g/cc and shear moduli ranging 1.3-14.55 kPa, allowing gray and white matter simulant tuning to a 30-35% difference in shear for biofidelity.

CONCLUSIONS:

These materials are intended for use as layered cranial phantoms in a shock tube and open field blasts, with focus on observing phenomena occurring at the interfaces of adjacent tissue simulant types or material-fluid boundaries. Mechanistic findings from these studies may be used to inform the design of protective gear to mitigate blast injuries.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos por Explosión / Lesiones Traumáticas del Encéfalo / Ciencia de los Materiales Límite: Animals / Humans Idioma: En Revista: Mil Med Año: 2020 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos por Explosión / Lesiones Traumáticas del Encéfalo / Ciencia de los Materiales Límite: Animals / Humans Idioma: En Revista: Mil Med Año: 2020 Tipo del documento: Article
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