Enantioconvergent alkylation of ketones with racemic secondary alcohols via hydrogen borrowing catalysis.
Chem Commun (Camb)
; 56(24): 3543-3546, 2020 Mar 24.
Article
en En
| MEDLINE
| ID: mdl-32104853
An enantioconvergent method for the alkylation of o-disubstituted aryl ketones with racemic secondary alcohols is described. This process is mediated by a commercially available iridium catalyst and proceeds via hydrogen borrowing catalysis. The highly enantioenriched ß-substituted ketone products were readily cleaved to a wide range of functional groups via retro-Friedel-Crafts acylation.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2020
Tipo del documento:
Article