A novel role for lipoxin A<sub>4</sub> in driving a lymph node-eye axis that controls autoimmunity to the neuroretina.

Wei, Jessica; Mattapallil, Mary J; Horai, Reiko; Jittayasothorn, Yingyos; Modi, Arnav P; Sen, H Nida; Gronert, Karsten; Caspi, Rachel R

A novel role for lipoxin A₄ in driving a lymph node-eye axis that controls autoimmunity to the neuroretina.

Wei, Jessica; Mattapallil, Mary J; Horai, Reiko; Jittayasothorn, Yingyos; Modi, Arnav P; Sen, H Nida; Gronert, Karsten; Caspi, Rachel R.

Afiliación

Wei J; Vision Science Program, University of California, Berkeley, Berkeley, United States.
Mattapallil MJ; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, United States.
Horai R; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, United States.
Jittayasothorn Y; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, United States.
Modi AP; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, United States.
Sen HN; School of Optometry, University of California, Berkeley, Berkeley, United States.
Gronert K; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, United States.
Caspi RR; Vision Science Program, University of California, Berkeley, Berkeley, United States.

Elife ; 92020 03 02.

Article en En | MEDLINE | ID: mdl-32118582

Asunto(s)

Autoinmunidad/fisiología; Ojo/inmunología; Lipoxinas/fisiología; Ganglios Linfáticos/fisiología; Retina/inmunología; Animales; Enfermedades Autoinmunes/inmunología; Linfocitos T CD4-Positivos/inmunología; Estudios de Casos y Controles; Homeostasis; Humanos; Lipoxinas/biosíntesis; Lipoxinas/genética; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Receptores CCR7/metabolismo; Receptores de Esfingosina-1-Fosfato/metabolismo; Uveítis/inmunología

Palabras clave

5-lipoxygenase; Ccr7; draining lymph node; effector t cells; human; immunology; inflammation; mouse; trafficking; uveitis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retina / Autoinmunidad / Lipoxinas / Ojo / Ganglios Linfáticos Tipo de estudio: Observational_studies Límite: Animals / Humans Idioma: En Revista: Elife Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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