Randomized control trial of opioid- versus nonopioid-based analgesia after thyroidectomy.
Surgery
; 167(6): 957-961, 2020 Jun.
Article
en En
| MEDLINE
| ID: mdl-32127178
ABSTRACT
BACKGROUND:
Opioid-based analgesia is the most common method for pain control in the postoperative period. Limited data exist to compare the adequacy of pain control in the post thyroidectomy period with nonopioid-based analgesia. We aimed to evaluate the efficacy of nonopioid-based, postoperative analgesia.METHODS:
After institutional review board approval, patients were randomized to 1 of 2 pain control regimens. Sample size was calculated to assess for a pain score difference of 1 based on a visual analog scale. The control group received opioid-based, postoperative analgesia, whereas the study group received nonopioid-based analgesia of acetaminophen and ibuprofen. Pain scores (measured on visual analog scale) and opioid use (converted to morphine equivalent dose) were measured after completion of the operation.RESULTS:
The sample sizes for the study and control groups were 49 and 46 patients, respectively. The pain score for the study and control groups 1 hour after the operation (3.3 vs 3.9, P = .35), 6 hours after the operation (2.8 vs 3.0, P = .08), on postoperative day 1 (1.6 vs 2.4, P = .08) and on the first office visit (0.2 vs 0.1, P = .82) did not have a statistically significant difference. Morphine equivalent opioid requirement for pain control in the postoperative period was 0.8 vs 6.9 mg (P < .01), respectively.CONCLUSION:
In a randomized control trial, we showed that patients treated with nonopioid analgesia had similar pain scores to those treated with opioids, with the benefit of having lower opioid exposure in the perioperative period.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
/
8_ODS3_consumo_sustancias_psicoactivas
Problema de salud:
2_sustancias_psicoativas
/
8_opioid_abuse
Asunto principal:
Dolor Postoperatorio
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Tiroidectomía
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Analgésicos no Narcóticos
/
Analgésicos Opioides
Tipo de estudio:
Clinical_trials
Límite:
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Surgery
Año:
2020
Tipo del documento:
Article