Diabetogenic effect of gluten in Wistar albino rats: a preliminary preclinical screening.
Med Pharm Rep
; 93(1): 47-52, 2020 Jan.
Article
en En
| MEDLINE
| ID: mdl-32133446
ABSTRACT
BACKGROUND AND AIMS:
Gluten-related disease affects less than 1% population and is not considered of relevance at the public health level. However, the consumption of a gluten-free diet has been most commonly adopted as a special diet worldwide in the recent past. In the present study, we investigated the association of gluten intake and diabetes in Wistar albino rats.METHODS:
Thirty adult Wistar rats were randomly divided into five groups control, diabetic, and test treated with pure gluten (100, 200 and 400 mg/kg body weight). Diabetes was induced in rats by intraperitoneal injection of Streptozotocin (65 mg/kg) after a dose of nicotinamide (110 mg/kg). Body weight, fasting blood glucose levels, postprandial blood glucose levels and histopathology of the pancreas were compared.RESULTS:
Fasting blood glucose levels and postprandial blood glucose were significantly higher in diabetes animals but there were no significant changes in gluten treated groups. Other parameters were not significantly changed among different groups.CONCLUSIONS:
Gluten at doses 100 mg/kg, 200 mg/kg and 400 mg/kg is not a diabetogenic diet and hence it needs not be excluded from diet for the prevention and management of Type 2 diabetes mellitus.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
Med Pharm Rep
Año:
2020
Tipo del documento:
Article
País de afiliación:
India