[Indicators of protein, lipid, carbohydrate, purine metabolism and the level of pituitary hormones in healthy men of 22-55 years old.]

ABSTRACT

The levels of total protein, glucose, cholesterol and its fractions, triglycerides, uric acid, prolactin, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone in the serum, blood pressure (BP), calculated body mass index (BMI) were analyzed in 60 healthy men aged 22-55 years old. To assess the age dynamics of the parameters, groups of young (up to 35 years old) and middle age (over 35 years old) were formed according to the classification adopted at the International Symposium on Age Periodization in 1965. The correlation analysis of the parameters of the biochemical parameters, level pituitary hormones, age, BMI, level of mean blood pressure was made. There are a decrease (p<0,05) of total blood protein level (within the normal range), a tendency to a decrease in prolactin levels (PRL), an increase (p<0,05) of total cholesterol, LDL cholesterol in middle age group compared with the younger group. HDL cholesterol levels did not differ in the groups; this demonstrates the constancy of antiatherogenic protection over many decades. A slight decrease in total protein in the blood and a tendency to a decrease in the level of PRL with increasing age against the background of a negative correlations between the low degree of PRL and age (r=-0,20; p=0,01), total protein and age (r=-0,35; p=0,01) confirm the participation of PRL in protein metabolism, and also indirectly indicate changes in the regulatory effect of dopamine on prolactin synthesis and secretion.