Your browser doesn't support javascript.
loading
Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration.
Chen, Chih-Lung; Huang, Wen-Yen; Wang, Eddy Hsi Chun; Tai, Kang-Yu; Lin, Sung-Jan.
Afiliación
  • Chen CL; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
  • Huang WY; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
  • Wang EHC; Department of Dermatology, Columbia University, New York, NY, USA.
  • Tai KY; Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei, Taiwan.
  • Lin SJ; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan. drsjlin@ntu.edu.tw.
J Biomed Sci ; 27(1): 43, 2020 Mar 14.
Article en En | MEDLINE | ID: mdl-32171310
Stem cell activity is subject to non-cell-autonomous regulation from the local microenvironment, or niche. In adaption to varying physiological conditions and the ever-changing external environment, the stem cell niche has evolved with multifunctionality that enables stem cells to detect these changes and to communicate with remote cells/tissues to tailor their activity for organismal needs. The cyclic growth of hair follicles is powered by hair follicle stem cells (HFSCs). Using HFSCs as a model, we categorize niche cells into 3 functional modules, including signaling, sensing and message-relaying. Signaling modules, such as dermal papilla cells, immune cells and adipocytes, regulate HFSC activity through short-range cell-cell contact or paracrine effects. Macrophages capacitate the HFSC niche to sense tissue injury and mechanical cues and adipocytes seem to modulate HFSC activity in response to systemic nutritional states. Sympathetic nerves implement the message-relaying function by transmitting external light signals through an ipRGC-SCN-sympathetic circuit to facilitate hair regeneration. Hair growth can be disrupted by niche pathology, e.g. dysfunction of dermal papilla cells in androgenetic alopecia and influx of auto-reacting T cells in alopecia areata and lichen planopilaris. Understanding the functions and pathological changes of the HFSC niche can provide new insight for the treatment of hair loss.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración / Células Madre / Folículo Piloso / Alopecia / Nicho de Células Madre / Cabello Límite: Animals / Humans Idioma: En Revista: J Biomed Sci Asunto de la revista: MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Taiwán

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración / Células Madre / Folículo Piloso / Alopecia / Nicho de Células Madre / Cabello Límite: Animals / Humans Idioma: En Revista: J Biomed Sci Asunto de la revista: MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Taiwán
...