Green preparation of dual-template chitosan-based magnetic water-compatible molecularly imprinted biopolymer.
Carbohydr Polym
; 236: 116102, 2020 May 15.
Article
en En
| MEDLINE
| ID: mdl-32172901
ABSTRACT
In the current study, a green method was used for the fabrication of dual-template chitosan-based magnetic water-compatible molecularly imprinted biopolymer in water without using organic and toxic reagents and then, its application as a sorbent for the simultaneous pre-concentration and determination of valsartan (VAL) and losartan (LOS) from urine samples followed by HPLC-UV. Chitosan was used as a multi-functional monomer due to its unique properties in terms of non-toxic, cost-effectiveness, readily available, biocompatible, biodegradable and easy to polymerize in mild condition. The proposed sorbent represents the exceptional properties in terms of green synthesis, high magnetic strength, bio-compatibility, high selectivity, fast equilibrium adsorption as well as high adsorption capacity. In the optimized conditions, the developed MMIP-DMSPE-HPLC/UV method showed a wide linear range of 5.0â¯-â¯1500.0⯵g L-1 for VAL and 8.0â¯-â¯1500⯵g L-1 for LOS and low LODs of 1.4 and 2.3⯵gâ¯L-1 for VAL and LOS, respectively with RSD% values less than 5.0, (nâ¯=â¯5). The obtained recoveries were 95.6-100.2 % for VAL and 92.0-98.1 % for LOS which showed the applicability of green, water-compatible and bio-compatibility of the proposed method for neat and selective extraction of VAL and LOS from complicated urine samples.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Losartán
/
Quitosano
/
Impresión Molecular
/
Nanopartículas de Magnetita
/
Valsartán
Idioma:
En
Revista:
Carbohydr Polym
Año:
2020
Tipo del documento:
Article
País de afiliación:
Irán