Nasal high flow improves ventilation during propofol sedation: A randomized cross-over study in healthy volunteers.
Respir Physiol Neurobiol
; 277: 103429, 2020 06.
Article
en En
| MEDLINE
| ID: mdl-32173607
ABSTRACT
OBJECTIVE:
Hypoventilation and carbon dioxide (CO2) retention are common during sedation. The current study investigated the ventilation responses to nasal high flow (NHF) during sedation with propofol.METHODS:
NHF of 30 L/min and 60 L/min with room air was applied during wakefulness and sedation in 10 male volunteers. Ventilation was monitored by respiratory inductance plethysmography, transcutaneous partial pressure of CO2 (TcCO2), and SpO2.RESULTS:
During sedation, NHF of 30 L/min and 60 L/min reduced the TcCO2 by 2.9 ± 2.7 mmHg (p = 0.025) and by 3.6 ± 3.4 mmHg (p = 0.024) without affecting SpO2 and reduced the mean respiratory rate by 3 ± 3 breaths/min (p = 0.011) and by 4 ± 3 breaths/min (p = 0.003), respectively.CONCLUSION:
During sedation with propofol, NHF without supplemental oxygen attenuated CO2 retention and reduced the respiratory rate. The findings show that NHF can improve ventilation during sedation, which may reduce the risk of complications related to hypoventilation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Terapia por Inhalación de Oxígeno
/
Vigilia
/
Propofol
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Ventilación Pulmonar
/
Frecuencia Respiratoria
/
Hipnóticos y Sedantes
Tipo de estudio:
Clinical_trials
Límite:
Adult
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Humans
/
Male
Idioma:
En
Revista:
Respir Physiol Neurobiol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón