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Diagnostic performance of peripheral leukocyte telomere G-tail length for detecting breast cancer.
Koi, Yumiko; Tsutani, Yasuhiro; Nishiyama, Yukie; Kanda, Miyuki; Shiroma, Yoshitomo; Yamamoto, Yuki; Sasada, Shinsuke; Akita, Tomoyuki; Masumoto, Norio; Kadoya, Takayuki; Takahashi, Ryou-U; Tanaka, Junko; Okada, Morihito; Tahara, Hidetoshi.
Afiliación
  • Koi Y; Surgical Oncology, Division of Radiation Biology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
  • Tsutani Y; Department of Surgical Oncology, Research Center for Radiation Casualty Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
  • Nishiyama Y; Department of Surgical Oncology, Research Center for Radiation Casualty Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
  • Kanda M; Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
  • Shiroma Y; Collaborative Laboratory of Liquid Biopsy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
  • Yamamoto Y; Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
  • Sasada S; Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
  • Akita T; Department of Surgical Oncology, Research Center for Radiation Casualty Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
  • Masumoto N; Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
  • Kadoya T; Department of Surgical Oncology, Research Center for Radiation Casualty Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
  • Takahashi RU; Department of Surgical Oncology, Research Center for Radiation Casualty Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
  • Tanaka J; Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
  • Okada M; Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
  • Tahara H; Department of Surgical Oncology, Research Center for Radiation Casualty Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Cancer Sci ; 111(5): 1856-1861, 2020 May.
Article en En | MEDLINE | ID: mdl-32249523
ABSTRACT
The telomere G-tail (G-tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte G-tail length of breast cancer (BC) patients and cancer-free individuals and evaluated the association between the G-tail length and the presence of BC. A significant shortening of the median G-tail length was observed in BC patients compared with cancer-free individuals and was found in the early phase of BC. Our study indicated that the leukocyte G-tail length might be a potential biomarker for BC detection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Telómero / Leucocitos Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Cancer Sci Año: 2020 Tipo del documento: Article País de afiliación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Telómero / Leucocitos Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Cancer Sci Año: 2020 Tipo del documento: Article País de afiliación: Japón