A kit based methodology for convenient formulation of 166Ho-Chitosan complex for treatment of liver cancer.
Appl Radiat Isot
; 161: 109161, 2020 Jul.
Article
en En
| MEDLINE
| ID: mdl-32250846
ABSTRACT
The effectiveness of 166Ho-chitosan complex as a radiopharmaceutical for trans-arterial radiation therapy of liver cancer has been established in clinical trials. We have developed a simple kit-bade strategy for convenient formulation of therapeutically relevant doses of 166Ho-chitosan complex in a hospital radiopharmacy in order to facilitate its widespread utilization. Quality control studies established the suitability of the radiopharmaceutical formulated using the developed strategy for in vivo administration. Biodistribution studies in normal Wistar rats showed excellent retention of the radiopharmaceutical in the liver, thus, paving the way towards utility of this approach in clinical context.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Radioisótopos
/
Radiofármacos
/
Quitosano
/
Holmio
/
Neoplasias Hepáticas
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Appl Radiat Isot
Asunto de la revista:
MEDICINA NUCLEAR
/
SAUDE AMBIENTAL
Año:
2020
Tipo del documento:
Article
País de afiliación:
India