Coombs-positive Paroxysmal Nocturnal Haemoglobinuria.
Oxf Med Case Reports
; 2020(3): omz125, 2020 Mar.
Article
en En
| MEDLINE
| ID: mdl-32257252
ABSTRACT
Autoimmune haemolytic anaemia (AIHA) and paroxysmal nocturnal haemoglobinuria (PNH) are two distinct causes of haemolytic anaemia. They have different mechanisms that underpin their pathogenesis and, therefore, require different treatment strategies. The direct antiglobulin test (DAT) or Coombs test is positive in cases of immune-mediated haemolytic anaemia and, thus, is positive in AIHA but negative in PNH. We report a case of a woman presenting with a haemolytic anaemia who was found to have concomitant evidence of AIHA and PNH. The case highlights the importance of carrying out a comprehensive haemolysis work-up in patients who present with haemolytic anaemia.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Oxf Med Case Reports
Año:
2020
Tipo del documento:
Article
País de afiliación:
Reino Unido