Biphasic Tracheal Relaxation Induced by Higenamine and Nantenine From Nandina domestica THUNBERG.
J Pharmacol Sci
; 115(2): 254-257, 2011.
Article
en En
| MEDLINE
| ID: mdl-32272546
ABSTRACT
We compared the effects of the extract from fruits of Nandina domestica THUNBERG (NDE) and its constituents, higenamine and nantenine, on contractile responses in isolated guineapig trachea. NDE (1 mg/ml) caused biphasic relaxation of the trachea precontracted with high-K+ stimulation the fast component was blocked by propranolol and mimicked by higenamine; and the slow was resistant to propranolol and mimicked by nantenine. Ca2+-induced contraction under high-K+ stimulation was antagonized by nantenine or NDE + propranolol. These results suggest that NDE relaxes the trachea quickly through ß-adrenoceptor stimulation by higenamine and slowly through Ca2+ antagonism by nantenine.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Pharmacol Sci
Asunto de la revista:
FARMACOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón