Metabolism of JQ1, an inhibitor of bromodomain and extra terminal bromodomain proteins, in human and mouse liver microsomes.

Li, Feng; MacKenzie, Kevin R; Jain, Prashi; Santini, Conrad; Young, Damian W; Matzuk, Martin M

Metabolism of JQ1, an inhibitor of bromodomain and extra terminal bromodomain proteins, in human and mouse liver microsomes.

Li, Feng; MacKenzie, Kevin R; Jain, Prashi; Santini, Conrad; Young, Damian W; Matzuk, Martin M.

Afiliación

Li F; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, USA.
MacKenzie KR; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Jain P; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, USA.
Santini C; NMR and Drug Metabolism Core, Advanced Technology Cores, Baylor College of Medicine Houston, TX, USA.
Young DW; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, USA.
Matzuk MM; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.

Biol Reprod ; 103(2): 427-436, 2020 08 04.

Article en En | MEDLINE | ID: mdl-32285106

Asunto(s)

Azepinas/farmacología; Microsomas Hepáticos/efectos de los fármacos; Proteínas Nucleares/metabolismo; Triazoles/farmacología; Animales; Humanos; Metabolómica; Ratones; Microsomas Hepáticos/metabolismo

Palabras clave

BRDT inhibitors; JQ1; cytochrome P450s; liver microsomes; metabolite identification

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azepinas / Triazoles / Microsomas Hepáticos / Proteínas Nucleares Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Biol Reprod Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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