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Insights Into Pneumococcal Pneumonia Using Lung Aspirates and Nasopharyngeal Swabs Collected From Pneumonia Patients in The Gambia.
Dunne, Eileen M; Hua, Yinglei; Salaudeen, Rasheed; Hossain, Ilias; Ndiaye, Malick; Ortika, Belinda D; Mulholland, E Kim; Hinds, Jason; Manna, Sam; Mackenzie, Grant A; Satzke, Catherine.
Afiliación
  • Dunne EM; Infection and Immunity, Murdoch Children's Research Institute, Parkville, Australia.
  • Hua Y; Department of Paediatrics, The University of Melbourne, Parkville, Australia.
  • Salaudeen R; Infection and Immunity, Murdoch Children's Research Institute, Parkville, Australia.
  • Hossain I; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Australia.
  • Ndiaye M; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
  • Ortika BD; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
  • Mulholland EK; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
  • Hinds J; Infection and Immunity, Murdoch Children's Research Institute, Parkville, Australia.
  • Manna S; Infection and Immunity, Murdoch Children's Research Institute, Parkville, Australia.
  • Mackenzie GA; Department of Paediatrics, The University of Melbourne, Parkville, Australia.
  • Satzke C; Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
J Infect Dis ; 225(8): 1447-1451, 2022 04 19.
Article en En | MEDLINE | ID: mdl-32319524
BACKGROUND: We investigated the pathogenesis of pneumococcal pneumonia using clinical specimens collected for pneumonia surveillance in The Gambia. METHODS: Lung aspirates and nasopharyngeal swabs from 31 patients were examined by culture, quantitative polymerase chain reaction (qPCR), whole genome sequencing, serotyping, and reverse-transcription qPCR. RESULTS: Five lung aspirates cultured pneumococci, with a matching strain identified in the nasopharynx. Three virulence genes including ply (pneumolysin) were upregulated >20-fold in the lung compared with the nasopharynx. Nasopharyngeal pneumococcal density was higher in pediatric pneumonia patients compared with controls (P < .0001). CONCLUSIONS: Findings suggest that changes in pneumococcal gene expression occurring in the lung environment may be important in pathogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 4_TD Problema de salud: 4_pneumonia Asunto principal: Infecciones Neumocócicas / Neumonía Neumocócica Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Child / Humans País/Región como asunto: Africa Idioma: En Revista: J Infect Dis Año: 2022 Tipo del documento: Article País de afiliación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 4_TD Problema de salud: 4_pneumonia Asunto principal: Infecciones Neumocócicas / Neumonía Neumocócica Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Child / Humans País/Región como asunto: Africa Idioma: En Revista: J Infect Dis Año: 2022 Tipo del documento: Article País de afiliación: Australia