Small heat shock proteins in neurodegenerative diseases.
Cell Stress Chaperones
; 25(4): 679-699, 2020 07.
Article
en En
| MEDLINE
| ID: mdl-32323160
ABSTRACT
Small heat shock proteins are ubiquitously expressed chaperones, yet mutations in some of them cause tissue-specific diseases. Here, we will discuss how small heat shock proteins give rise to neurodegenerative disorders themselves while we will also highlight how these proteins can fulfil protective functions in neurodegenerative disorders caused by protein aggregation. The first half of this paper will be focused on how mutations in HSPB1, HSPB3, and HSPB8 are linked to inherited peripheral neuropathies like Charcot-Marie-Tooth (CMT) disease and distal hereditary motor neuropathy (dHMN). The second part of the paper will discuss how small heat shock proteins are linked to neurodegenerative disorders like Alzheimer's, Parkinson's, and Huntington's disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Enfermedad de Charcot-Marie-Tooth
/
Enfermedad de Huntington
/
Proteínas de Choque Térmico Pequeñas
/
Enfermedad de Alzheimer
Límite:
Humans
Idioma:
En
Revista:
Cell Stress Chaperones
Año:
2020
Tipo del documento:
Article
País de afiliación:
Bélgica