Melt Amorphisation of Orlistat with Mesoporous Silica Using a Supercritical Carbon Dioxide: Effects of Pressure, Temperature, and Drug Loading Ratio and Comparison with Other Conventional Amorphisation Methods.

Park, Heejun; Cha, Kwang-Ho; Hong, Seung Hyeon; Abuzar, Sharif Md; Ha, Eun-Sol; Kim, Jeong-Soo; Kim, Min-Soo; Hwang, Sung-Joo

Park, Heejun; Cha, Kwang-Ho; Hong, Seung Hyeon; Abuzar, Sharif Md; Ha, Eun-Sol; Kim, Jeong-Soo; Kim, Min-Soo; Hwang, Sung-Joo.

Afiliación

Park H; College of Pharmacy, Pusan National University, 63 Busandaehak-ro, Geumjeong-gu, Busan 46241, Korea.
Cha KH; Yonsei Institute of Pharmaceutical Sciences & College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea.
Hong SH; Yonsei Institute of Pharmaceutical Sciences & College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea.
Abuzar SM; Yonsei Institute of Pharmaceutical Sciences & College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea.
Ha ES; College of Pharmacy, Pusan National University, 63 Busandaehak-ro, Geumjeong-gu, Busan 46241, Korea.
Kim JS; Dong-A ST Co. Ltd., Giheung-gu, Yongin, Gyeonggi 446-905, Korea.
Kim MS; College of Pharmacy, Pusan National University, 63 Busandaehak-ro, Geumjeong-gu, Busan 46241, Korea.
Hwang SJ; Yonsei Institute of Pharmaceutical Sciences & College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea.

Pharmaceutics ; 12(4)2020 Apr 20.

Article en En | MEDLINE | ID: mdl-32326103

Palabras clave

dissolution; melt-amorphisation; mesoporous silica; orlistat; supercritical carbon dioxide

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2020 Tipo del documento: Article