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Design, synthesis and discovery of 2(1H)-quinolone derivatives for the treatment of pulmonary fibrosis through inhibition of TGF-ß/smad dependent and independent pathway.
Xue, Linlin; Deng, Dexin; Zheng, Shoujun; Tang, Minghai; Yang, Zhuang; Pei, Heying; Chen, Yong; Yang, Tao; Liu, Kongjun; Ye, Haoyu; Chen, Lijuan.
Afiliación
  • Xue L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, 610041, PR China.
  • Deng D; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, 610041, PR China.
  • Zheng S; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, 610041, PR China.
  • Tang M; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, 610041, PR China.
  • Yang Z; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, 610041, PR China.
  • Pei H; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, 610041, PR China.
  • Chen Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, 610041, PR China.
  • Yang T; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, 610041, PR China.
  • Liu K; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, 610041, PR China.
  • Ye H; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, 610041, PR China. Electronic address: haoyu_ye@scu.edu.cn.
  • Chen L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, 610041, PR China. Electronic address: chenlijuan125@163.com.
Eur J Med Chem ; 197: 112259, 2020 Jul 01.
Article en En | MEDLINE | ID: mdl-32334267
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Quinolonas / Fibrosis Pulmonar Idiopática Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Quinolonas / Fibrosis Pulmonar Idiopática Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article