Your browser doesn't support javascript.
loading
Lipidomics Reveals Reduced Inflammatory Lipid Species and Storage Lipids after Switching from EFV/FTC/TDF to RPV/FTC/TDF: A Randomized Open-Label Trial.
Curran, Adrian; Rull, Anna; Navarro, Jordi; Vidal-González, Judit; Martin-Castillo, Mario; Burgos, Joaquin; Falcó, Vicenç; Ribera, Esteban; Torrella, Ariadna; Planas, Bibiana; Peraire, Joaquim; Crespo, Manuel.
Afiliación
  • Curran A; Infectious Diseases Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
  • Rull A; Vall d'Hebron Institut de Recerca (VHIR), 085035 Barcelona, Spain.
  • Navarro J; Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, 43005 Tarragona, Spain.
  • Vidal-González J; Infectious Diseases Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
  • Martin-Castillo M; Vall d'Hebron Institut de Recerca (VHIR), 085035 Barcelona, Spain.
  • Burgos J; Vall d'Hebron Institut de Recerca (VHIR), 085035 Barcelona, Spain.
  • Falcó V; Department of Internal Medicine - Hepatology, Hospital Universitari Vall d'Hebron (HUVH), 08035 Barcelona, Spain.
  • Ribera E; Vall d'Hebron Institut de Recerca (VHIR), 085035 Barcelona, Spain.
  • Torrella A; Infectious Diseases Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
  • Planas B; Vall d'Hebron Institut de Recerca (VHIR), 085035 Barcelona, Spain.
  • Peraire J; Infectious Diseases Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
  • Crespo M; Vall d'Hebron Institut de Recerca (VHIR), 085035 Barcelona, Spain.
J Clin Med ; 9(5)2020 Apr 25.
Article en En | MEDLINE | ID: mdl-32344934
HIV and antiretroviral therapy affect lipid metabolism. Lipidomics quantifies several individual species that are overlooked using conventional biochemical analyses, outperforming traditional risk equations. We aimed to compare the plasma lipidomic profile of HIV patients taking efavirenz (EFV) or rilpivirine (RPV). Patients ≥ 18 years old on EFV co-formulated with emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) with HIV-RNA < 50 copies/mL for ≥6 months were randomized to continue EFV/FTC/TDF (n = 14) or switch to RPV/FTC/TDF (n =15). Lipidomic analyses conducted by mass spectrometry (MS) were performed at baseline and after 12 and 24 weeks. OWLiver® Care and OWLiver® tests were performed to estimate the presence of fatty liver disease (NAFLD). No significant differences (83% male, median age 44 years, 6 years receiving EFV/FTC/TDF, CD4+ count 740 cells/mm3, TC 207 [57 HDL-C/133 LDL-C] mg/dL, TG 117 mg/dL) were observed between the groups at baseline. Significant reductions in plasma lipids and lipoproteins but increased circulating bilirubin concentrations were observed in patients who switched to RPV/FTC/TDF. Patients on RPV/FTC/TDF showed a decrease in the global amount of storage lipids (-0.137 log2 [fold-change] EFV vs. 0.059 log2 [fold-change] RPV) but an increase in lysophosphatidylcholines (LPCs) and total steroids. Compared with EFV, RPV increased metabolites with anti-inflammatory properties and reduced the repository of specific lipotoxic lipids.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: J Clin Med Año: 2020 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: J Clin Med Año: 2020 Tipo del documento: Article País de afiliación: España
...