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Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein.
Li, Jiexin; Chen, Zhuojia; Chen, Feng; Xie, Guoyou; Ling, Yuyi; Peng, Yanxi; Lin, Yu; Luo, Nan; Chiang, Cheng-Ming; Wang, Hongsheng.
Afiliación
  • Li J; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
  • Chen Z; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
  • Chen F; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
  • Xie G; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
  • Ling Y; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
  • Peng Y; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
  • Lin Y; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
  • Luo N; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital,Southern Medical University, Guangzhou, Guangdong 510006, China.
  • Chiang CM; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
  • Wang H; Simmons Comprehensive Cancer Center, Department of Pharmacology, and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Nucleic Acids Res ; 48(10): 5684-5694, 2020 06 04.
Article en En | MEDLINE | ID: mdl-32356894
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Proteínas Asociadas a CRISPR / Sistemas CRISPR-Cas / Desmetilasa de ARN, Homólogo 5 de AlkB Límite: Humans Idioma: En Revista: Nucleic Acids Res Año: 2020 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Proteínas Asociadas a CRISPR / Sistemas CRISPR-Cas / Desmetilasa de ARN, Homólogo 5 de AlkB Límite: Humans Idioma: En Revista: Nucleic Acids Res Año: 2020 Tipo del documento: Article País de afiliación: China