Host transcriptomic signature as alternative test-of-cure in visceral leishmaniasis patients co-infected with HIV.

Adriaensen, Wim; Cuypers, Bart; Cordero, Carlota F; Mengasha, Bewketu; Blesson, Séverine; Cnops, Lieselotte; Kaye, Paul M; Alves, Fabiana; Diro, Ermias; van Griensven, Johan

Adriaensen, Wim; Cuypers, Bart; Cordero, Carlota F; Mengasha, Bewketu; Blesson, Séverine; Cnops, Lieselotte; Kaye, Paul M; Alves, Fabiana; Diro, Ermias; van Griensven, Johan.

Afiliación

Adriaensen W; Unit of Neglected Tropical Diseases, Department of Clinical Sciences, Institute of Tropical Medicine, Nationalestraat 122, 2000 Antwerp, Belgium. Electronic address: wadriaensen@itg.be.
Cuypers B; Unit of Molecular Parasitology, Department of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat 122, 2000 Antwerp, Belgium; Adrem Data Lab, Department of Mathematics and Computer Science, University of Antwerp, Middelheim 1, 2020 Antwerp, Belgium.
Cordero CF; Unit of Neglected Tropical Diseases, Department of Clinical Sciences, Institute of Tropical Medicine, Nationalestraat 122, 2000 Antwerp, Belgium.
Mengasha B; Leishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia.
Blesson S; Drugs for Neglected Diseases initiative, 15 Chemin Louis-Dunant, 1202 Geneva, Switzerland.
Cnops L; Unit of Neglected Tropical Diseases, Department of Clinical Sciences, Institute of Tropical Medicine, Nationalestraat 122, 2000 Antwerp, Belgium.
Kaye PM; York Biomedical Research Institute, University of York, United Kingdom.
Alves F; Drugs for Neglected Diseases initiative, 15 Chemin Louis-Dunant, 1202 Geneva, Switzerland.
Diro E; Leishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia.
van Griensven J; Unit of Neglected Tropical Diseases, Department of Clinical Sciences, Institute of Tropical Medicine, Nationalestraat 122, 2000 Antwerp, Belgium.

EBioMedicine ; 55: 102748, 2020 May.

Article en En | MEDLINE | ID: mdl-32361248

Asunto(s)

Antiprotozoarios/uso terapéutico; Leishmania donovani/efectos de los fármacos; Leishmaniasis Visceral/tratamiento farmacológico; Leishmaniasis Visceral/genética; Transcriptoma; Adulto; Anfotericina B/uso terapéutico; Coinfección; Endorribonucleasas/sangre; Endorribonucleasas/genética; Femenino; Regulación de la Expresión Génica; VIH/patogenicidad; Infecciones por VIH/virología; Interacciones Huésped-Patógeno/genética; Humanos; Interleucina-10/sangre; Interleucina-10/genética; Leishmania donovani/crecimiento & desarrollo; Leishmania donovani/patogenicidad; Leishmaniasis Visceral/parasitología; Leishmaniasis Visceral/patología; Masculino; Fagosomas/metabolismo; Fagosomas/parasitología; Fosforilcolina/análogos & derivados; Fosforilcolina/uso terapéutico; Receptores Histamínicos H4/sangre; Receptores Histamínicos H4/genética; Recurrencia; Serina Proteasas/sangre; Serina Proteasas/genética; Insuficiencia del Tratamiento

Palabras clave

Blood signature; HIV; RNA signature; Treatment efficacy; Visceral leishmaniasis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND Problema de salud: 2_enfermedades_transmissibles / 3_zoonosis Asunto principal: Leishmania donovani / Transcriptoma / Leishmaniasis Visceral / Antiprotozoarios Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: EBioMedicine Año: 2020 Tipo del documento: Article

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