[Short peptides: regulation of skin function during aging.]
Adv Gerontol
; 33(1): 46-54, 2020.
Article
en Ru
| MEDLINE
| ID: mdl-32362083
ABSTRACT
Short peptides are applied for supporting skin function during ageing, because they can permeate the intact stratum corneum of the epidermis and affect the cells of the dermis. Short peptides are part of natural metabolism of cells and many of them have geroprotective properties. In the review we are considering the base sorts of peptides that are used for normalized skin fibroblasts function matrikines, carnosine, collagen peptides, cytokine and growth factor analogs, defensins, immunoprotective peptides and polyfunctional peptides. Polyfunctional peptides (AcSDKP, KED, AEDG, AED) have geroprotective properties, slow apoptosis and stimulate skin cell proliferation, also increase functional activity of skin fibroblasts, normalize intracellular matrix hemostasis. Polyfunctional peptides are the antioxidants and immunoprotectors and can activate microcirculation in dermis. Peptide regulation of skin function during ageing are the fast-developing and prospective area in molecular gerontology.
Palabras clave
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Envejecimiento de la Piel
/
Dermis
Límite:
Humans
Idioma:
Ru
Revista:
Adv Gerontol
Asunto de la revista:
GERIATRIA
Año:
2020
Tipo del documento:
Article