A bio-inspired injectable hydrogel as a cell platform for real-time glycaemic regulation.
J Mater Chem B
; 8(21): 4627-4641, 2020 06 07.
Article
en En
| MEDLINE
| ID: mdl-32373901
ABSTRACT
Frequent subcutaneous insulin injection and islet transplantation are promising therapeutic options for type 1 diabetes mellitus. However, poor patient compliance, insufficient appropriate islet ß cell donors and body immune rejection limit their clinical applications. The design of a platform capable of encapsulating insulin-secreting cells and achieving real-time blood glucose regulation, is a so far unmet need. Herein, inspired by the natural processes of regulating blood glucose in pancreatic islet ß cells, we developed a poly(N-isopropylacrylamide-co-dextran-maleic acid-co-3-acrylamidophenylboronic acid) (P(AAPBA-Dex-NIPAM)) hydrogel as a cell platform with glucose responsiveness and thermo-responsiveness for the therapy of diabetes. This platform showed good biocompatibility against insulin-secreting cells and presented glucose-dependent insulin release behaviour. The bioinspired P(AAPBA6-Dex-NIPAM64) hydrogel had a positive effect on real-time glycaemic regulation, as observed by intraperitoneal glucose tolerance tests. The non-fasting blood glucose of diabetic rats was restored to a normal level during the period of treatment. Additionally, the inflammatory response did not occur after administration of the platform. Collectively, we expected that the bio-mimetic platform combined with an insulin-secreting capability could be a new diabetic treatment strategy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glucemia
/
Dextranos
/
Hidrogeles
/
Diabetes Mellitus Experimental
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Diabetes Mellitus Tipo 1
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Células Secretoras de Insulina
/
Hipoglucemiantes
Límite:
Animals
Idioma:
En
Revista:
J Mater Chem B
Año:
2020
Tipo del documento:
Article
País de afiliación:
China