Collateral fitness effects of mutations.

Mehlhoff, Jacob D; Stearns, Frank W; Rohm, Dahlia; Wang, Buheng; Tsou, Erh-Yeh; Dutta, Nisita; Hsiao, Meng-Hsuan; Gonzalez, Courtney E; Rubin, Alan F; Ostermeier, Marc

Mehlhoff, Jacob D; Stearns, Frank W; Rohm, Dahlia; Wang, Buheng; Tsou, Erh-Yeh; Dutta, Nisita; Hsiao, Meng-Hsuan; Gonzalez, Courtney E; Rubin, Alan F; Ostermeier, Marc.

Afiliación

Mehlhoff JD; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Stearns FW; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Rohm D; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Wang B; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Tsou EY; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Dutta N; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Hsiao MH; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Gonzalez CE; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.
Rubin AF; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Ostermeier M; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.

Proc Natl Acad Sci U S A ; 117(21): 11597-11607, 2020 05 26.

Article en En | MEDLINE | ID: mdl-32385156

Asunto(s)

Evolución Molecular; Aptitud Genética/genética; Mutación Missense/genética; Mutación Missense/fisiología; Escherichia coli/enzimología; Escherichia coli/genética; Escherichia coli/fisiología; Proteínas de Escherichia coli/química; Proteínas de Escherichia coli/genética; Proteínas de Escherichia coli/metabolismo; beta-Lactamasas/química; beta-Lactamasas/genética; beta-Lactamasas/metabolismo

Palabras clave

beta-lactamase; fitness landscape; protein aggregation; protein evolution; stress response

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_neglected_diseases / 3_zoonosis Asunto principal: Evolución Molecular / Mutación Missense / Aptitud Genética Tipo de estudio: Risk_factors_studies Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article

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