A head-to-head Caco-2 assay comparison of the mechanisms of action of the intestinal permeation enhancers: SNAC and sodium caprate (C<sub>10</sub>).

Twarog, Caroline; Liu, Kai; O'Brien, Peter J; Dawson, Kenneth A; Fattal, Elias; Illel, Brigitte; Brayden, David J

A head-to-head Caco-2 assay comparison of the mechanisms of action of the intestinal permeation enhancers: SNAC and sodium caprate (C₁₀).

Twarog, Caroline; Liu, Kai; O'Brien, Peter J; Dawson, Kenneth A; Fattal, Elias; Illel, Brigitte; Brayden, David J.

Afiliación

Twarog C; UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland; UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
Liu K; UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland; UCD School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.
O'Brien PJ; UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Dawson KA; UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland; UCD School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.
Fattal E; School of Pharmacy, Institut Galien, CNRS, Univ. Paris-Sud, Univ. Paris-Saclay, 92290 Châtenay-Malabry, France.
Illel B; Drug Product Development, Small Molecules Oral Platform, Sanofi Research and Development, Montpellier, France.
Brayden DJ; UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland; UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: david.brayden@ucd.ie.

Eur J Pharm Biopharm ; 152: 95-107, 2020 Jul.

Article en En | MEDLINE | ID: mdl-32387703

Asunto(s)

Caprilatos/química; Ácidos Decanoicos/química; Absorción Intestinal/efectos de los fármacos; Mucosa Intestinal/metabolismo; Intestinos/efectos de los fármacos; Permeabilidad/efectos de los fármacos; Células CACO-2; Línea Celular Tumoral; Membrana Celular/efectos de los fármacos; Membrana Celular/metabolismo; Impedancia Eléctrica; Humanos; Uniones Estrechas/efectos de los fármacos; Uniones Estrechas/metabolismo

Palabras clave

Excipient cytotoxicity; Intestinal permeation enhancers; Oral peptide delivery; SNAC; Sodium caprate; Tight junctions

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Permeabilidad / Caprilatos / Ácidos Decanoicos / Absorción Intestinal / Mucosa Intestinal / Intestinos Límite: Humans Idioma: En Revista: Eur J Pharm Biopharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Irlanda

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