Lactoferrin reduces mycobacterial M1-type inflammation induced with trehalose 6,6'-dimycolate and facilitates the entry of fluoroquinolone into granulomas.

Nguyen, Thao K T; Niaz, Zainab; d'Aigle, John; Hwang, Shen-An; Kruzel, Marian L; Actor, Jeffrey K

Nguyen, Thao K T; Niaz, Zainab; d'Aigle, John; Hwang, Shen-An; Kruzel, Marian L; Actor, Jeffrey K.

Afiliación

Nguyen TKT; Department of Pathology and Laboratory Medicine, UTHealth McGovern Medical School, Houston, TX 77030, USA.
Niaz Z; The University of Texas MD Anderson Cancer Center, UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
d'Aigle J; Department of Pathology and Laboratory Medicine, UTHealth McGovern Medical School, Houston, TX 77030, USA.
Hwang SA; Department of Pathology and Laboratory Medicine, UTHealth McGovern Medical School, Houston, TX 77030, USA.
Kruzel ML; The University of Texas MD Anderson Cancer Center, UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Actor JK; Department of Pathology and Laboratory Medicine, UTHealth McGovern Medical School, Houston, TX 77030, USA.

Biochem Cell Biol ; 99(1): 73-80, 2021 02.

Article en En | MEDLINE | ID: mdl-32402212

Asunto(s)

Granuloma/metabolismo; Inflamación/metabolismo; Lactoferrina/metabolismo; Mycobacterium/metabolismo; Animales; Factores Cordón; Femenino; Fluoroquinolonas; Granuloma/inducido químicamente; Humanos; Lactoferrina/química; Ratones; Ratones Endogámicos C57BL; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo

Palabras clave

M1/M2 phenotype; granuloma; granulome; immunopathologie; immunopathology; lactoferrin; lactoferrine; phénotype M1/M2; trehalose 6,6'-dimycolate; tréhalose 6,6'-dimycolate; tuberculose; tuberculosis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_tuberculosis Asunto principal: Granuloma / Inflamación / Lactoferrina / Mycobacterium Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Biochem Cell Biol Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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