The effect of chronic neuropeptide-S treatment on non-motor parameters in experimental model of Parkinson's disease.
Int J Neurosci
; 131(8): 765-774, 2021 Aug.
Article
en En
| MEDLINE
| ID: mdl-32441169
ABSTRACT
AIM:
Besides motor impairment, non-motor symptoms including cognitive decline, anxiety, and depression are observed in Parkinson's Disease (PD). The aim of this study was to investigate whether chronic administration of central neuropeptide-S (NPS) improves non-motor symptoms in 6-hydroxydopamine (6-OHDA)-induced parkinsonian rats. MATERIAL ANDMETHODS:
Experimental PD was utilized by unilateral stereotaxic injection of the 6-OHDA into the medial forebrain bundle (MFB), while the sham-operated animals underwent the same surgical procedures. NPS (1 nmol) or vehicle was daily administered through an intracerebroventricular (icv) cannula for 7 days. Radial arm maze (RAM) test was used to evaluate the working memory; whereas, elevated plus maze (EPM) test and sucrose preference test were used to monitor the anxiety and depression status, respectively. The levels of dopamine, glutamic acid, and glutamine was determined in harvested striatal and hippocampal tissue samples. The immunoreactivities for tyrosine hydroxylase (TH) was determined using immunohistochemistry.RESULTS:
In the RAM test, the 6-OHDA-induced increases in the reference and working memory errors were reduced by the central NPS administration. The decreased sucrose preference in the parkinsonian rats was increased by centrally administered NPS. The levels of dopamine levels in striatum and hippocampus were decreased in the parkinsonian rats, however, they were not altered by the centrally administered NPS. Additionally, NPS treatment significantly attenuated the 6-OHDA-induced loss of TH neuronal number.CONCLUSION:
Consequently, NPS appears to be a therapeutic candidate for the treatment of non-motor complications of PD.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conducta Animal
/
Neuropéptidos
/
Sustancias Protectoras
/
Trastornos Parkinsonianos
Límite:
Animals
Idioma:
En
Revista:
Int J Neurosci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Turquía