Macrophages and T Lymphocytes in the Ovine Placenta After Experimental Infection With Toxoplasma gondii.
Vet Pathol
; 57(4): 545-549, 2020 07.
Article
en En
| MEDLINE
| ID: mdl-32452287
ABSTRACT
Early abortion in ovine toxoplasmosis has had limited investigation. This study evaluated the immune response in the placenta of sheep orally infected with Toxoplasma gondii and euthanized between 2 and 4 weeks postinfection. Toxoplasma infection of the placenta was only found at 4 weeks after infection. Parasitic debris in foci of necrosis were immunolabeled in the maternal caruncle, whereas well-preserved intracellular parasitic vacuole-like structures were found in trophoblasts of fetal cotyledon. Early abortions had increased macrophages in caruncular septa, whereas in later abortions the placentas containing the parasite had an increase of T lymphocytes and macrophages mainly in the fetal cotyledons. This study suggests that the immune response in both the fetal and maternal compartments of the placenta may contribute to the pathogenesis of ovine toxoplasmosis and that these responses differ between early and late presentations of the disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Enfermedades de las Ovejas
/
Linfocitos T
/
Toxoplasmosis Animal
/
Aborto Veterinario
/
Macrófagos
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Vet Pathol
Año:
2020
Tipo del documento:
Article
País de afiliación:
España