Telocytes in the Myocardium of Children with Congenital Heart Disease Tetralogy of Fallot.
Bull Exp Biol Med
; 169(1): 137-146, 2020 May.
Article
en En
| MEDLINE
| ID: mdl-32488790
ABSTRACT
Telocytes, a new type of interstitial stem cells with long thin processes that form a three-dimensional network around cardiomyocytes, vessels, and nerve fibers were described in the myocardium of children with tetralogy of Fallot. Two types of morphologically different telocytes, spindle-shaped and rounded, were identified. Contacts of telocytes with stem cells and interstitial macrophages were found. Telocytes were more common in the immature myocardium, where the assembly of myofibrils in cardiomyocytes was not completed and small Ki-67+ cardiomyocyte progenitor cells were present. Telocytes expressed immunohistochemical markers CD117, vimentin, CD34, and CD44. Localization and ultrastructural characteristics of telocytes suggested their participation in stem cell differentiation, coordination of neoangiogenesis, and paracrine regulation of all components of the interstitium.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tetralogía de Fallot
/
Telocitos
/
Miocardio
Tipo de estudio:
Prognostic_studies
Límite:
Child, preschool
/
Humans
/
Infant
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2020
Tipo del documento:
Article
País de afiliación:
Rusia