Non-invasive lobular neoplasia of the breast: Morphologic features, clinical presentation, and management dilemmas.
Breast J
; 26(6): 1148-1155, 2020 06.
Article
en En
| MEDLINE
| ID: mdl-32500575
ABSTRACT
The designation of noninvasive lobular neoplasia applies to atypical epithelial proliferations composed of noncohesive cells secondary to loss or functional alteration of E-cadherin-mediated cell adhesion. The morphologic spectrum of noninvasive lobular neoplasia encompasses atypical lobular hyperplasia (ALH) and classic lobular carcinoma in situ (classic LCIS) and two LCIS variants, namely florid LCIS (F-LCIS) and pleomorphic LCIS (P-LCIS), as defined in the World Health Organization (WHO) Classification of Tumors of the Breast 5th ed. Herein, we review the morphologic, immunohistochemical, and molecular features of noninvasive lobular neoplasia, with special emphasis on F-LCIS and P-LCIS. We also review imaging features, management at core needle biopsy, upgrade rates at surgical excision, and clinical management dilemmas.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
11_ODS3_cobertura_universal
/
2_ODS3
Problema de salud:
11_delivery_arrangements
/
2_cobertura_universal
Asunto principal:
Neoplasias de la Mama
/
Carcinoma in Situ
/
Carcinoma Lobular
/
Carcinoma de Mama in situ
Límite:
Female
/
Humans
Idioma:
En
Revista:
Breast J
Asunto de la revista:
NEOPLASIAS
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos