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Lack of association between LGMN and Alzheimer's disease in the Southern Han Chinese population.
Zhang, Xinyue; Jiao, Bin; Weng, Ling; Zhou, Yafang; Guo, Lina; Wang, Xin; Zhou, Lu; Liu, Xixi; Xiao, Xuewen; Liu, Hui; Zhu, Xiangyu; Li, Chenping; Zhu, Yuan; Yang, Qijie; Lin, Zhuojie; Jiang, Yaling; Wen, Yafei; Zhou, Hui; Shen, Lu; Liao, Xinxin.
Afiliación
  • Zhang X; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Jiao B; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Weng L; National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China.
  • Zhou Y; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China.
  • Guo L; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Wang X; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Zhou L; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Liu X; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Xiao X; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Liu H; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Zhu X; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Li C; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Zhu Y; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Yang Q; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Lin Z; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Jiang Y; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Wen Y; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Zhou H; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Shen L; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
  • Liao X; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Eur J Neurosci ; 52(8): 4009-4017, 2020 10.
Article en En | MEDLINE | ID: mdl-32506655
Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid ß-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). However, the genetic role of LGMN in AD has not been clearly elucidated. Here, we used Sanger sequencing to investigate the single independent (single-variant association test) and cumulative (gene-based association test) effects of variants in the LGMN gene as potential susceptibility factors for AD, in a cohort comprising 676 AD cases and 365 elderly controls from the Han population of South China. In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD. The results of our replication study in the Alzheimer's Disease Neuroimaging Initiative cohort also showed no association between LGMN and AD. These findings suggest that the LGMN gene may not be a critical factor for AD development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Risk_factors_studies Límite: Aged / Humans País/Región como asunto: Asia Idioma: En Revista: Eur J Neurosci Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Risk_factors_studies Límite: Aged / Humans País/Región como asunto: Asia Idioma: En Revista: Eur J Neurosci Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China