Fecal microbiota transplantation in the treatment of intestinal steroid-resistant graft-versus-host disease: two case reports and a review of the literature.
J Int Med Res
; 48(6): 300060520925693, 2020 Jun.
Article
en En
| MEDLINE
| ID: mdl-32527171
ABSTRACT
Acute graft-versus-host disease (aGvHD) reduces the efficiency and safety of allogeneic hematopoietic stem cell transplantation (allo-HSCT). In recent years, attempts have been made to transplant fecal microbiota from healthy donors to treat intestinal GvHD. This study presented two cases of patients undergoing allo-HSCT who were later selected for fecal microbiota transplantation (FMT). In the first patient, FMT resulted in the complete resolution of symptoms, whereas therapeutic efficacy was not achieved in the second patient. FMT eliminated drug-resistant pathogens, namely very drug-resistant Enterococcus spp., but not multidrug-resistant Acinetobacter baumannii or Candida spp. Further research is needed, particularly on the safety of FMT in patients with intestinal steroid-resistant GvHD and on the distant impact of transplanted microflora on the outcomes of allo-HSCT. FMT appears promising for the treatment of patients with steroid-resistant GvHD.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
/
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
3_zoonosis
/
6_leukemia
Asunto principal:
Trasplante de Células Madre Hematopoyéticas
/
Disbiosis
/
Trasplante de Microbiota Fecal
/
Glucocorticoides
/
Enfermedad Injerto contra Huésped
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Int Med Res
Año:
2020
Tipo del documento:
Article
País de afiliación:
Polonia