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Safety and immunogenicity of a mosquito saliva peptide-based vaccine: a randomised, placebo-controlled, double-blind, phase 1 trial.
Manning, Jessica E; Oliveira, Fabiano; Coutinho-Abreu, Iliano V; Herbert, Samantha; Meneses, Claudio; Kamhawi, Shaden; Baus, Holly Ann; Han, Alison; Czajkowski, Lindsay; Rosas, Luz Angela; Cervantes-Medina, Adriana; Athota, Rani; Reed, Susan; Mateja, Allyson; Hunsberger, Sally; James, Emma; Pleguezuelos, Olga; Stoloff, Gregory; Valenzuela, Jesus G; Memoli, Matthew J.
Afiliación
  • Manning JE; Laboratory of Malaria and Vector Research, National Institutes of Health, Bethesda, MD, USA. Electronic address: jessica.manning@nih.gov.
  • Oliveira F; Laboratory of Malaria and Vector Research, National Institutes of Health, Bethesda, MD, USA.
  • Coutinho-Abreu IV; Laboratory of Malaria and Vector Research, National Institutes of Health, Bethesda, MD, USA.
  • Herbert S; Laboratory of Malaria and Vector Research, National Institutes of Health, Bethesda, MD, USA.
  • Meneses C; Laboratory of Malaria and Vector Research, National Institutes of Health, Bethesda, MD, USA.
  • Kamhawi S; Laboratory of Malaria and Vector Research, National Institutes of Health, Bethesda, MD, USA.
  • Baus HA; LID Clinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Han A; LID Clinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Czajkowski L; LID Clinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Rosas LA; LID Clinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Cervantes-Medina A; LID Clinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Athota R; LID Clinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Reed S; LID Clinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Mateja A; Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, sponsored by the National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
  • Hunsberger S; Biostatistics Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • James E; SEEK, PepTcell, London, UK.
  • Pleguezuelos O; SEEK, PepTcell, London, UK.
  • Stoloff G; SEEK, PepTcell, London, UK.
  • Valenzuela JG; Laboratory of Malaria and Vector Research, National Institutes of Health, Bethesda, MD, USA.
  • Memoli MJ; LID Clinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Lancet ; 395(10242): 1998-2007, 2020 06 27.
Article en En | MEDLINE | ID: mdl-32534628
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_enfermedades_transmissibles Asunto principal: Saliva / Adyuvantes Inmunológicos / Transmisión de Enfermedad Infecciosa / Inmunogenicidad Vacunal Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Lancet Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_enfermedades_transmissibles Asunto principal: Saliva / Adyuvantes Inmunológicos / Transmisión de Enfermedad Infecciosa / Inmunogenicidad Vacunal Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Lancet Año: 2020 Tipo del documento: Article