Survivin expression starts before hepatocellular cancer development in the liver of chronic hepatitis B patients: a pilot, cross-sectional study.
Prz Gastroenterol
; 15(2): 138-143, 2020.
Article
en En
| MEDLINE
| ID: mdl-32550946
ABSTRACT
INTRODUCTION:
Survivin expression is well known feature of hepatocellular carcinoma (HCC); however, there is no information about survivin expression in chronic hepatitis B (CHB).AIM:
Investigating survivin expression in the liver of CHB patients. MATERIAL ANDMETHODS:
This is a single-centre, cross-sectional study. Seventy-five CHB patients and eight control patients were enrolled into the study between 2008 and 2018. Immunohistochemical study was performed by using anti-survivin antibody to evaluate survivin immunoreactivity.RESULTS:
Survivin immunoreactivity was significantly higher in CHB patients compared to controls (p = 0.008). Also, the degree of survivin immunoreactivity was significantly higher in CHB patients (p = 0.027). Between the anti-survivin-positive and anti-survivin-negative groups, baseline laboratory parameters and initial pathology features were not significantly different.CONCLUSIONS:
This is the first study evaluating survivin expression in CHB patients. Understanding the possible relationship between survivin expression and HCC development in this population can promote new studies in terms of new therapies and treatment timing.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_enfermedades_transmissibles
Tipo de estudio:
Observational_studies
/
Prevalence_studies
Idioma:
En
Revista:
Prz Gastroenterol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Turquía