Evaluation of antibiotic-induced behavioral changes in mice.
Physiol Behav
; 223: 113015, 2020 09 01.
Article
en En
| MEDLINE
| ID: mdl-32553641
ABSTRACT
Gut microbiota (GM) plays a critical role in health maintenance. Previous reports connected GM with metabolic, immunologic and neurologic pathways. The main purpose of the current investigation was to study whether antibiotic-induced disturbances of GM affects psychological or behavioral conditions on mice as animal model. Mice were exposed to clindamycin or amoxicillin, and their behaviors were evaluated. Antibiotic-treated groups displayed reduced recognition memory and increased depression. No significant changes in the locomotor activity and anxiety were observed. Our data suggested that changes in GM composition by antibiotics may lead to the cognitive and behavioral deficit.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_zoonosis
Asunto principal:
Microbioma Gastrointestinal
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
Physiol Behav
Año:
2020
Tipo del documento:
Article