Neocurromycin A, a new GRP78 downregulator from Streptomyces sp. RAI364.
J Antibiot (Tokyo)
; 73(11): 790-793, 2020 11.
Article
en En
| MEDLINE
| ID: mdl-32572166
ABSTRACT
A new curromycin-related compound, neocurromycin A (2), was isolated from the fermented broth of Streptomyces sp. RAI364. The molecular formula of 2 was established as C35H44N4O7 by ESI-MS and the structure was elucidated by NMR spectroscopic analyses. Neocurromycin A showed selective cytotoxicity against MKN45 human gastric cancer cells in a nutrient-deprived medium with an IC50 of 380 nM and inhibited the expression of the molecular chaperone GRP78 in HT1080 G-L cells in the presence of 10 mM of 2-deoxyglucose with an IC50 of 1.7 µM.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Streptomyces
/
Proteínas de Choque Térmico
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón