Sleep characteristics and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact older adults: The CABLE study.
Alzheimers Dement
; 16(8): 1146-1152, 2020 08.
Article
en En
| MEDLINE
| ID: mdl-32657026
ABSTRACT
INTRODUCTION:
This study tested the self-reported sleep characteristics associated with cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers in cognitively intact older adults.METHODS:
The linear and non-linear regression analyses were conducted in 736 cognitively normal participants (mean [standard deviation; SD] age, 62.3 [10.5] years, range 40 to 88 years, 59% female) who had measurements of cerebrospinal fluid (CSF) amyloid beta (Aß) and tTau proteins and sleep characteristics, after adjusting for age, gender, education, apolipoprotein E gene (APOE) ε4 status, and general cognition.RESULTS:
Greater daytime sleepiness was associated with higher CSF indicators of amyloid deposition in female patients. No significant associations were revealed for CSF tTau proteins after Bonferroni correction. A U-shaped relationship was revealed for nocturnal sleep habits, such that those with insufficient or excessive nocturnal sleep duration had greater CSF biomarkers of amyloid deposition (the reflection range bedtime around 1000 p.m. and sleep duration 6.0 to 6.5 hours).DISCUSSION:
These findings consolidated the close relationship between sleep and AD.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sueño
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Biomarcadores
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Péptidos beta-Amiloides
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Proteínas tau
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Enfermedad de Alzheimer
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Alzheimers Dement
Año:
2020
Tipo del documento:
Article
País de afiliación:
China