Differential diagnosis of pancreatic cysts: A prospective study on the role of intra-cystic glucose concentration.
Dig Liver Dis
; 52(9): 1026-1032, 2020 09.
Article
en En
| MEDLINE
| ID: mdl-32675041
ABSTRACT
BACKGROUND:
The accuracy and costs of current diagnostic methods in the differential diagnosis of pancreatic cystic lesions still has ample room for improvement.AIMS:
The aim of the study was to confirm the diagnostic yield of intracystic glucose in the diagnosis of pancreatic cyst subtypes.METHODS:
We prospectively recruited all patients who underwent Endoscopic Ultrasound with Fine Needle Aspiration of pancreatic cyst at our Institution.RESULTS:
Fifty-six patients were included in the study. We found that intracystic glucose concentration < 50â¯mg/dL was significantly more sensitive than a concentration of Carcinoembryonic Antigen > 192â¯ng/mL (93.6% vs 54.8%; pâ¯=â¯0.003) for the diagnosis of mucinous cysts. In terms of specificity, the two markers were not different (96% vs 100%; pâ¯=â¯1). Regarding the diagnosis of non-mucinous cysts, intracystic glucose concentration ≥ 50â¯mg/mL showed higher sensitivity than Carcinoembryonic Antigen level < 5â¯ng/mL (96% vs 72%) although a statistical significance could not be reached (pâ¯=â¯0.07). The two markers were not statistically different in terms of specificity (93.6% vs 87.1%; pâ¯=â¯0.62).CONCLUSION:
Given its diagnostic performance and ease of measurement, intracystic glucose may replace Carcinoembryonic Antigen in the differential diagnosis of mucinous versus non-mucinous pancreatic cysts.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quiste Pancreático
/
Neoplasias Pancreáticas
/
Antígeno Carcinoembrionario
/
Cistoadenoma
/
Neoplasias Intraductales Pancreáticas
/
Glucosa
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Dig Liver Dis
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2020
Tipo del documento:
Article