The Effect of Nucleus Size on the Cell Dose in Targeted Radionuclide Therapy - A Monte Carlo Study.
J Med Signals Sens
; 10(2): 113-118, 2020.
Article
en En
| MEDLINE
| ID: mdl-32676447
ABSTRACT
BACKGROUND:
Nowadays, the use of radiopharmaceuticals in medicine is unavoidable. Depending on the distribution of the radiopharmaceutical in the cells, the nucleus absorbed dose changes by the variations in their geometry size. Therefore, this study aims to investigate the S-value by the variation of nucleus size using Geant4 toolkit.METHODS:
Two spherical cells with a variety of nucleus size have been considered as the cancerous cell. Monoenergetic electrons ranging from 5 to 300 keV are distributed uniformly. The S-value for four target-source components (including NucleusâCytoplasm, NucleusâCell surface, NucleusâNucleus, and NucleusâNucleus surface) is computed and plotted. Then, the obtained data are compared with analytical Medical Internal Radiation Dose (MIRD) data.RESULTS:
In NucleusâCytoplasm compartment for electrons below 10 keV, obtained S-values show a slight decrease for the nucleus in the radii of around half of the cell radius and then S-values increase with the increase in the nucleus radii. In the S-value of NucleusâCell surface, for all electron energy levels, a slight decrease observed with the increase of nucleus radii. For NucleusâNucleus and NucleusâNucleus surface cases, with an increase in the size of the cell nucleus, a sharp reduction in the S-values is detected.CONCLUSION:
It can be concluded that for the beta emitters with low-energy radiation (<40 keV), the S-value is heavily dependent on the nucleus size which may affect the treatment of small tumors. While for the beta emitters with higher-energy radiation (>100 keV), the size of the nucleus is not very noticeable in the induced S-value.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
Problema de salud:
1_financiamento_saude
Idioma:
En
Revista:
J Med Signals Sens
Año:
2020
Tipo del documento:
Article
País de afiliación:
Irán