Wernicke-Kleist-Leonhard phenotypes of endogenous psychoses: a review of their validityâ©.
Dialogues Clin Neurosci
; 22(1): 37-49, 2020 03.
Article
en En
| MEDLINE
| ID: mdl-32699504
ABSTRACT
While the ICD-DSM paradigm has been a major advance in clinical psychiatry, its usefulness for biological psychiatry is debated. By defining consensus-based disorders rather than empirically driven phenotypes, consensus classifications were not an implementation of the biomedical paradigm. In the field of endogenous psychoses, the Wernicke-Kleist-Leonhard (WKL) pathway has optimized the descriptions of 35 major phenotypes using common medical heuristics on lifelong diachronic observations. Regarding their construct validity, WKL phenotypes have good reliability and predictive and face validity. WKL phenotypes come with remarkable evidence for differential validity on age of onset, familiality, pregnancy complications, precipitating factors, and treatment response. Most impressive is the replicated separation of high- and low-familiality phenotypes. Created in the purest tradition of the biomedical paradigm, the WKL phenotypes deserve to be contrasted as credible alternatives with other approaches currently under discussion.â©.
RESUMEN
Mettre la traduction ES.
Mettre la traduction FR.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_sustancias_psicoativas
Asunto principal:
Fenotipo
/
Trastornos Psicóticos
/
Encefalopatía de Wernicke
/
Manual Diagnóstico y Estadístico de los Trastornos Mentales
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Dialogues Clin Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Francia