Nutrients, Mitochondrial Function, and Perinatal Health.
Nutrients
; 12(7)2020 Jul 21.
Article
en En
| MEDLINE
| ID: mdl-32708345
ABSTRACT
Mitochondria are active independent organelles that not only meet the cellular energy requirement but also regulate central cellular activities. Mitochondria can play a critical role in physiological adaptations during pregnancy. Differences in mitochondrial function have been found between healthy and complicated pregnancies. Pregnancy signifies increased nutritional requirements to support fetal growth and the metabolism of maternal and fetal tissues. Nutrient availability regulates mitochondrial metabolism, where excessive macronutrient supply could lead to oxidative stress and contribute to mitochondrial dysfunction, while micronutrients are essential elements for optimal mitochondrial processes, as cofactors in energy metabolism and/or as antioxidants. Inadequate macronutrient and micronutrient consumption can result in adverse pregnancy outcomes, possibly through mitochondrial dysfunction, by impairing energy supply, one-carbon metabolism, biosynthetic pathways, and the availability of metabolic co-factors which modulate the epigenetic processes capable of establishing significant short- and long-term effects on infant health. Here, we review the importance of macronutrients and micronutrients on mitochondrial function and its influence on maternal and infant health.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Embarazo
/
Nutrientes
/
Micronutrientes
/
Fenómenos Fisiologicos Nutricionales Maternos
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Ingestión de Alimentos
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Metabolismo Energético
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Salud del Lactante
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Salud Materna
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Fenómenos Fisiológicos Nutricionales del Lactante
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Intercambio Materno-Fetal
Límite:
Female
/
Humans
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Male
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Newborn
Idioma:
En
Revista:
Nutrients
Año:
2020
Tipo del documento:
Article
País de afiliación:
México