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CHOP and c-JUN up-regulate the mutant Z α1-antitrypsin, exacerbating its aggregation and liver proteotoxicity.
Attanasio, Sergio; Ferriero, Rosa; Gernoux, Gwladys; De Cegli, Rossella; Carissimo, Annamaria; Nusco, Edoardo; Campione, Severo; Teckman, Jeffrey; Mueller, Christian; Piccolo, Pasquale; Brunetti-Pierri, Nicola.
Afiliación
  • Attanasio S; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.
  • Ferriero R; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.
  • Gernoux G; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • De Cegli R; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.
  • Carissimo A; Institute for Applied Mathematics "Mauro Picone" National Research Council, Naples, Italy.
  • Nusco E; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.
  • Campione S; Pathology Unit, Cardarelli Hospital, Naples, Italy.
  • Teckman J; St. Louis University School of Medicine, St. Louis, Missouri, USA.
  • Mueller C; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA; Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Piccolo P; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy; Department of Translational Medicine, Federico II University, Naples, Italy. Electronic address: piccolo@tigem.it.
  • Brunetti-Pierri N; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy; Department of Translational Medicine, Federico II University, Naples, Italy. Electronic address: brunetti@tigem.it.
J Biol Chem ; 295(38): 13213-13223, 2020 09 18.
Article en En | MEDLINE | ID: mdl-32723872
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alfa 1-Antitripsina / Proteínas Proto-Oncogénicas c-jun / Factor de Transcripción CHOP / Agregación Patológica de Proteínas / Hígado / Hepatopatías / Mutación Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alfa 1-Antitripsina / Proteínas Proto-Oncogénicas c-jun / Factor de Transcripción CHOP / Agregación Patológica de Proteínas / Hígado / Hepatopatías / Mutación Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Italia