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Dissecting Murine Muscle Stem Cell Aging through Regeneration Using Integrative Genomic Analysis.
Shcherbina, Anna; Larouche, Jacqueline; Fraczek, Paula; Yang, Benjamin A; Brown, Lemuel A; Markworth, James F; Chung, Carolina H; Khaliq, Mehwish; de Silva, Kanishka; Choi, Jeongmoon J; Fallahi-Sichani, Mohammad; Chandrasekaran, Sriram; Jang, Young C; Brooks, Susan V; Aguilar, Carlos A.
Afiliación
  • Shcherbina A; Department of Biomedical Informatics, Stanford University, Palo Alto, CA 94305, USA.
  • Larouche J; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
  • Fraczek P; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
  • Yang BA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
  • Brown LA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Markworth JF; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Chung CH; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
  • Khaliq M; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Program in Cancer Biology, University of Michigan, Ann Arbor, MI 48109, USA.
  • de Silva K; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
  • Choi JJ; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA; Wallace Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta,
  • Fallahi-Sichani M; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22903, USA.
  • Chandrasekaran S; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
  • Jang YC; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA; Wallace Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta,
  • Brooks SV; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Aguilar CA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: caguilar@umich.edu.
Cell Rep ; 32(4): 107964, 2020 07 28.
Article en En | MEDLINE | ID: mdl-32726628
ABSTRACT
During aging, there is a progressive loss of volume and function in skeletal muscle that impacts mobility and quality of life. The repair of skeletal muscle is regulated by tissue-resident stem cells called satellite cells (or muscle stem cells [MuSCs]), but in aging, MuSCs decrease in numbers and regenerative capacity. The transcriptional networks and epigenetic changes that confer diminished regenerative function in MuSCs as a result of natural aging are only partially understood. Herein, we use an integrative genomics approach to profile MuSCs from young and aged animals before and after injury. Integration of these datasets reveals aging impacts multiple regulatory changes through significant differences in gene expression, metabolic flux, chromatin accessibility, and patterns of transcription factor (TF) binding activities. Collectively, these datasets facilitate a deeper understanding of the regulation tissue-resident stem cells use during aging and healing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Senescencia Celular / Células Satélite del Músculo Esquelético Aspecto: Patient_preference Límite: Animals Idioma: En Revista: Cell Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Senescencia Celular / Células Satélite del Músculo Esquelético Aspecto: Patient_preference Límite: Animals Idioma: En Revista: Cell Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos